Related Experiment Video
Updated: Sep 25, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Is mammalian aging genetically controlled?
1University of Namur (FUNDP), Unit on Cellular Biology (URBC), Rue de Bruxelles, 61, 5000 Namur, Belgium. jpnitya@senescence.info
Abstract:
The rate of aging is species-specific, indicating that aging has a strong genetic component. Amongst mammals, the synchronization of the aging process suggests the presence of genetic determinants. In addition, single gene manipulations can change the rate of aging and demonstrate how a few genetic factors can regulate aging. Therefore, I propose that aging is regulated by a small set of genetic mechanisms, a single clock. If we can find what these regulatory mechanisms are, then instead of trying to delay age-related pathologies one by one we may be able to discover how to delay the entire aging process and most, if not all, of its pathologies.
More Related Videos
10:39A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
08:52Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
Published on: April 6, 2022
Related Concept Videos
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Mitochondria
Replicative Cell Senescence
Replicative Cell Senescence
Animal Mitochondrial Genetics
PI3K/mTOR/AKT Signaling Pathway