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Updated: Jun 22, 2026

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
Published on: April 4, 2014
Zn-proline catalyzed direct aldol reaction in aqueous media
Tamis Darbre1, Miguel Machuqueiro
1Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012, Switzerland. darbre@ioc.unibe.ch
Abstract:
Zn complexes of proline, lysine and arginine are efficient catalysts for the aldol addition of p-nitrobenzaldehyde and acetone in aqueous medium, giving quantitative yields and enantiomeric excesses up to 56% with 5 mol% of the catalysts at room temperature.
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