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Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands
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JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1

Susumu Hirabayashi1, Makiko Tajima, Ikuko Yao

  • 1Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan.

Molecular and Cellular Biology
|May 30, 2003
PubMed
Summary

Junctional adhesion molecule 4 (JAM4) interacts with MAGI-1, forming a novel protein complex at tight junctions. This JAM4-MAGI-1 complex enhances cell adhesion and regulates epithelial barrier function.

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