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[Anti-emetic effect of ethanol extract from "Wuzhuyu broth"]
Ting Zhang1, Min-wei Wang, Si-wei Chen
1Shanghai Institute of Materia Medica, Shanghai 200031, China.
Objective:
To investigate the anti-emetic effect of ethanol extract from "WuZhuYu broth" and its mechanism.
Method:
Three experiments were carried out test which extract has anti-emetic activity, such as CuSO4-induced pigeon's emetic response, gastric emptying in mice and ACh-induced or 5-HT-induced contraction in vitro gastric muscle in rats. Meanwhile, effect of anti-emetic extract on concentration-response curve to ACh, 5-HT, histamine was investigated.
Result:
50% ethanol extract and 70% ethanol extract were identified as having significantly stronger anti-emetic activities with little side effect, which showed the significant effect on concentration-response curve to ACh, 5-HT, histamine.
Conclusion:
50% ethanol extract and 70% ethanol extract contain more anti-emetic fractions, more anti-emetic fractions can be gained at the concentrations of 50% and 70% ethanol; the mechanism of anti-emetic effect is related to its antagonism to the receptors of ACh, 5-HT, histamine.
