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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
Published on: February 20, 2018
[Alterations of G proteins in heart diseases]
Liang Zhang1, Li Li, Li-Ling Wu
1Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083.
Abstract:
Guanine nucleotide binding proteins (G proteins), known as an important signal transduction molecular, can physiologically couple extracellular signals identified by G protein-coupled receptors (GPCRs) to a series of intracellular effector to cause changes of gene transcription and protein's structure and function. Members of G protein family including Gs, Gi/o, Gq/11, and G12/13 express in the myocardium. In the heart G protein-mediated signal transduction generates diverse effects on myocardiac contractility, heart rate, heart rhythm, and myocyte growth. This review focuses on alterations of G protein in cardiac hypertrophy, heart failure, acute myocardial ischemia, and arrhythmia to help us to understand the pathogenesis and pathophysiology in heart diseases.
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