Related Experiment Videos
Chromosomal abnormalities as a cause of recurrent abortions: a hospital experience
1Department of Pathology, The Aga Khan University Hospital, Karachi.
Objective:
To analyze the chromosomal abnormalities in couples with history of recurrent abortions.
Design:
Retrospective study.
Setting:
Cytogenetic section, Department of Pathology at the Aga Khan University Hospital, Karachi, Pakistan.
Patients:
Three hundred couples with history of recurrent abortions.
Main Outcome Measure:
Structural chromosomal abnormalities in carrier couples.
Results:
G-banded chromosomes were analyzed from both partners of 300 couples who had had two or more spontaneous abortions. Sixteen (5.3%) couples showed a chromosomal aberration in one of the partners. Seven translocations, 5 inversions, 2 deletions and 2 sex chromosomal abnormalities were identified. There was an increase in structural aberations, which was not significantly different from that reported worldwide.
Conclusion:
Chromosomal analysis is advocated as a primary tool in the evaluation of couples with repetitive fetal wastage.