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Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
Published on: January 6, 2015
Measuring the lung function in the mouse: the challenge of size
Charles G Irvin1, Jason H T Bates
1Vermont Lung Center, Department of Medicine, College of Medicine, University of Vermont, Room 226, HSRF, 149 Beaumont Avenue, Burlington, VT 05405, USA. Charles.Irvin@uvm.edu
Respiratory Research
|June 5, 2003
Summary
Measuring mouse lung function advances disease knowledge. Recent progress overcomes challenges in assessing lung mechanics in small animals, offering new insights into lung disease mechanisms.
Area of Science:
- Pulmonary Medicine
- Respiratory Physiology
- Animal Models
Background:
- Assessing lung function in mice is crucial for understanding lung disease.
- The small size of mice presents technical challenges for accurate lung function measurement.
- Previous methods often compromised precision for non-invasiveness, limiting data interpretation.
Purpose of the Study:
- To highlight recent advancements in mouse lung function assessment.
- To discuss the potential of these new methods to deepen our understanding of lung disease.
- To emphasize the importance of valid and useful measures of lung function in laboratory animals.
Main Methods:
- Development of sophisticated indices for measuring lung function in intact mice.
- Focus on overcoming precision and non-invasiveness compromises.
- Application in various models of lung disease.
Main Results:
- Significant progress has been made in developing valid and useful measures of mouse lung function.
- Current methods allow for sophisticated indices of lung function measurement in laboratory animals.
- These advances facilitate the study of drug, mediator, and infectious agent effects.
Conclusions:
- Improved mouse lung function assessment is vital for advancing lung disease research.
- New techniques offer greater precision and reliability in measuring lung mechanics.
- These developments are expected to yield important insights into lung disease mechanisms.
