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[Circadian variations in proinflammatory cytokine concentrations in acute myocardial infarction]
Alberto Domínguez Rodríguez1, Pedro Abreu González, Martín J García
1Servicio de Cardiología. Hospital Universitario Nuestra Señora de Candelaria. Santa Cruz de Tenerife. España.
Insights
Interleukin 6 levels show significant daily variations in acute myocardial infarction patients and controls. These proinflammatory cytokine levels are higher in patients, indicating a potential link to tissue damage and circadian rhythms.
Area of Science:
- Cardiology
- Immunology
- Chronobiology
Background:
- Proinflammatory cytokines are elevated in acute coronary syndrome.
- Coronary ischemic events exhibit diurnal variations.
- Circadian patterns in cytokine levels are not well-established in myocardial infarction.
Purpose of the Study:
- To investigate circadian variations in proinflammatory cytokine concentrations.
- To compare cytokine levels between acute myocardial infarction patients and controls.
Main Methods:
- 40 acute myocardial infarction patients and 40 controls were studied.
- Interleukin 6 and Interleukin 1 beta levels were measured.
- Blood samples were collected during nighttime (3:00 a.m.) and daytime (10:00 a.m.).
Main Results:
- Interleukin 6 levels varied significantly between day and night in both groups.
- Acute myocardial infarction patients had higher Interleukin 6 concentrations than controls.
- Interleukin 1 beta levels did not show significant diurnal variation.
Conclusions:
- Interleukin 6 exhibits circadian variation in both healthy individuals and myocardial infarction patients.
- Elevated Interleukin 6 in myocardial infarction may be a response to tissue damage.
- Circadian variations can influence physiological and biochemical measurements.
Introduction And Objectives:
The concentration of certain proinflammatory cytokines has been found to be elevated in patients with acute coronary syndrome. Many studies have shown that coronary ischemic accidents do not show a uniform distribution throughout the day, but instead exhibit rhythmic variations. The objective of this study is to determine whether there is a circadian pattern of variation in the concentrations of proinflammatory cytokines in patients with acute myocardial infarction.
Patients And Method:
The sample included 40 patients with acute myocardial infarction and 40 controls. Levels of interleukin 6 and 1 beta were determined in the first 24 hours after the acute coronary ischemic episode. Blood samples were extracted at 3:00 a.m. (period of darkness) and at 10:00 a.m. (period of daylight).
Results:
Both groups were similar in age, sex distribution, and coronary risk factors. Interleukin 6 levels showed a significant variation between daylight and nighttime concentrations in patients with acute myocardial infarction and controls (41.93 5.90/100.39 13.60 vs 25.76 4.45/52.67 7.73 pg/ml). However, interleukin 6 concentrations were higher in the acute myocardial infarction group than in the control group. Interleukin 1 beta concentrations did not vary between daylight and darkness.
Conclusions:
In both the control group and acute myocardial infarction group, interleukin 6 concentrations varied between daylight and darkness. Patients with acute myocardial infarction shown a higher concentration of interleukin 6 secondary to the physiological response to tissue damage. Circadian variations can affect the measurements obtained for different physiological and biochemical parameters.