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Effect of 3-hydroxyproline residues on collagen stability

Cara L Jenkins1, Lynn E Bretscher, Ilia A Guzei

  • 1Contribution from the Department of Chemistry and Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Journal of the American Chemical Society
|June 6, 2003
PubMed
Summary

The study reveals that 3-hydroxy-l-proline (3-Hyp) can destabilize collagen triple helices, unlike 4-hydroxy-l-proline (4-Hyp). Its position within the collagen sequence significantly impacts this destabilizing effect on protein stability.

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