Related Experiment Videos
Comparison among different insulin sensitivity indices in obese patients
E Mannucci1, G Bardini, F Rotella
1Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Florence, Italy.
Summary
Insulin sensitivity (IS) indices derived from fasting glucose and insulin correlate better with diabetes than fasting insulin alone. Post-load indices offer no additional benefit over fasting measurements for assessing insulin resistance.
Area of Science:
- Endocrinology
- Metabolic Syndrome Research
- Clinical Diagnostics
Background:
- Insulin sensitivity (IS) is crucial for metabolic health.
- Various indices exist to quantify IS, but their comparative efficacy is debated.
- Obesity is a major risk factor for insulin resistance and type 2 diabetes.
Purpose of the Study:
- To compare fasting insulin levels with different IS indices in obese individuals.
- To evaluate the association of these indices with diabetes and other metabolic abnormalities.
Main Methods:
- 767 obese outpatients (BMI > 30 kg/m²) without known diabetes were studied.
- Fasting and post-load (75g glucose) glucose and insulin levels were measured.
- Insulin sensitivity indices including Homeostasis Model Assessment (HOMA) and post-load indices (ISI) were calculated.
Main Results:
- Diabetes was diagnosed in approximately 21% of participants.
- All tested IS indices correlated with fasting/post-load glucose, triglycerides, and HDL-cholesterol.
- The HOMA index showed a stronger association with diabetes compared to fasting insulin alone.
Conclusions:
- Fasting-based IS indices demonstrate a stronger association with diabetes than fasting insulin.
- Post-load IS indices do not provide advantages over fasting-based indices.
- Fasting-based IS indices are valuable for assessing diabetes risk in obese populations.