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Murine intestinal migrating motor complexes: longitudinal components.

A K Powell1, R A R Bywater

  • 1Department of Physiology, Monash University, Victoria, Australia. andrew.powell@vcp.monash.edu.au

Neurogastroenterology and Motility
|June 6, 2003
PubMed
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This study reports spontaneous longitudinal muscle contractions in the mouse intestine, similar to circular muscle activity. These contractions are neurally coordinated and influenced by various neurotransmitters and drugs.

Area of Science:

  • Gastroenterology
  • Neurogastroenterology
  • Muscle Physiology

Background:

  • Spontaneous migrating contractions are known in the circular muscle of the mouse colon and ileum.
  • Equivalent spontaneous events in the longitudinal muscle layer were previously unreported.

Purpose of the Study:

  • To characterize spontaneous longitudinal muscle shortenings in the murine colon and ileum.
  • To investigate the neural organization and pharmacological modulation of these contractions.

Main Methods:

  • Recording of longitudinal muscle shortenings in isolated mouse colon and ileum.
  • Pharmacological assessment using tetrodotoxin, hexamethonium, morphine, nitric oxide, 5-hydroxytryptamine, hyoscine, and nifedipine.
  • Surgical sectioning of the colon to assess regional differences.

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Main Results:

  • Spontaneous longitudinal muscle shortenings were recorded, exhibiting similar characteristics to circular muscle migrating motor complexes.
  • These contractions were abolished by tetrodotoxin, hexamethonium, and morphine, indicating neural organization.
  • Nitric oxide decreased frequency, while 5-hydroxytryptamine increased frequency.
  • Hyoscine abolished ileal shortenings and reduced colonic shortening amplitude; nifedipine abolished shortenings.
  • Colonic longitudinal contractions occurred independently in different regions, with the distal colon showing greatest amplitude and lowest frequency.

Conclusions:

  • Spontaneous longitudinal muscle shortenings in the murine intestine are neurally coordinated events.
  • This longitudinal muscle preparation provides a model for studying novel pharmacological agents on colonic and ileal migrating motor complexes.