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Updated: Aug 17, 2026

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
Published on: March 3, 2015
Molecular regulation of urokinase-receptor gene expression as one potential concept for molecular staging and therapy
1Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Marchioninistr. 15, 81377 Munich, Germany.
Abstract:
The urokinase-receptor (u-PAR) is a central molecule of invasion and metastasis promoting plasminogen-dependent extracellular matrix degradation in diverse carcinoma types such as gastric or colon cancer. Overexpression of u-PAR has been reported to occur mainly at the transcriptional level in malignant cells, and has been shown to indicate a poor clinical prognosis of cancer patients. This review will give an overview on experimental findings on u-PAR and its function, molecular mechanisms of its regulation, and its impact for future clinical decision planning and potential therapeutic concepts.
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