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Synthesis of louisianin C
John M Beierle1, Ekundayo B Osimboni, Costa Metallinos
1Department of Chemistry, Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA.
The Journal of Organic Chemistry
|June 7, 2003
Abstract:
The synthesis of louisianin C (3), a member of a small family of 3,4,5-trisubstituted pyridyl natural products, is achieved in six steps and 11% overall yield starting from commercially available 3,5-dibromopyridine. The key step is a fluoride-induced desilylation-cyclization to afford carbinol 12.