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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

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Diastolic mitral regurgitation in patients with first-degree atrioventricular block

T Ishikawa1, K Kimura, N Miyazaki

  • 1Second Department of Internal Medicine, Yokohama City University Urafune Hospital, Japan.

Pacing and Clinical Electrophysiology : PACE
|November 1, 1992
PubMed

Insights

First-degree AV block and prolonged AV delay in DDD pacemakers can cause diastolic mitral regurgitation. Shortening the PQ interval reduces regurgitation duration, highlighting the link between delayed ventricular contraction and mitral valve function.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology

Background:

  • Diastolic mitral regurgitation (DMR) is linked to DDD pacemakers with prolonged atrioventricular (AV) delay.
  • The association between DMR and first-degree AV block requires further investigation.

Purpose of the Study:

  • To investigate transmitral blood flow and diastolic mitral regurgitation in patients with first-degree AV block and DDD pacemakers.
  • To determine the relationship between AV conduction intervals and the occurrence/duration of DMR.

Main Methods:

  • Pulsed Doppler echocardiography used to assess transmitral blood flow.
  • Evaluated 24 patients with first-degree AV block and 9 patients with DDD pacemakers.
  • Administered atropine to assess changes in AV intervals and DMR duration.

Main Results:

  • DMR observed in 19 of 24 patients with first-degree AV block.
  • Atropine shortened PQ interval and DMR duration, with a strong correlation (r=0.92).
  • Prolonged AV delay in DDD pacemaker patients also induced DMR, with a critical PQ interval of 0.23s.

Conclusions:

  • Delayed ventricular contraction following atrial contraction, as seen in first-degree AV block and prolonged AV delay, is associated with diastolic mitral regurgitation.
  • The duration of DMR is significantly influenced by the PQ interval.

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