Related Experiment Video
Updated: Aug 7, 2026

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
Published on: March 29, 2019
Transcription and the territory: the ins and outs of gene positioning
1Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. ruth.williams@csc.mrc.ac.uk
Abstract:
When cells exit mitosis, the neat rod-like chromosomes decondense into their interphase state. However, the chromatin threads are not randomly dispersed throughout the nucleoplasm. Rather, individual chromosomes appear to be organized into discrete, non-overlapping "territories". Current studies attempt to unravel how gene loci are organized within these territories, whether their subterritorial positions are dependent on transcription, and the extent to which the loci can move.
Related Concept Videos
Organization of Genes
Transcription
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Organization of Genes
Chromatin Position Affects Gene Expression
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the timing and level of...
Transcription
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Structure of a Gene
However, only 1% of the DNA is composed of genes that encode proteins; the rest, 99% is non-coding DNA. This non-coding DNA performs...

