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An evolutionary approach reveals a high protein-coding capacity of the human genome
Anton Nekrutenko1, Wen Yu Chung, Wen Hsiung Li
1Department of Ecology and Evolution, The University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA.
Trends in Genetics : TIG
|June 13, 2003
Abstract:
We developed a new evolutionary method for identifying exons from genomic sequences and found 19000 potential coding exons that are absent from all existing annotations of the human genome. Of these, 13700 satisfied very stringent criteria and can with confidence be considered as novel exons. Evidently, a large number of new human genes can be identified using evolutionary approaches.