Direct and cross-protective effects of heat adaptation in cultured cells

The model of 6-day dosed heat adaptation was developed on cultured rat H9c2 cardiomyoblasts and mouse C2c12 myoblasts. Heat adaptation produced a direct protective effect and increased the resistance of cells to heat shock. The cross-protective effect of heat adaptation was manifested in an increase in the resistance to staurosporine-induced damage. Heat adaptation did not protect cells from oxidative damage. As differentiated from adaptation of the organism, heat adaptation produces direct and cross-protective effects that develop due to the action of environmental factors in the absence of neurohumoral agents. It should be emphasized that the cross-protective effect of heat adaptation in cultured cells is specific to a certain type of damage.