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Acute generalized exanthematous pustulosis induced by terbinafine
Rosa Taberner1, Lluis Puig, Montserrat Gilaberte
1Department of Dermatology, Hospital de Son Llàtzer, Carretera de Manacor, Km. 4, Son Ferriol, 07198 Palma de Mallorca, Spain. rtaberne@hsll.es
European Journal of Dermatology : EJD
|June 14, 2003
Summary
Terbinafine, an antifungal, can cause rare but severe skin reactions. This case study details a patient who developed acute generalized exanthematous pustulosis after taking oral terbinafine.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Terbinafine is a widely prescribed allylamine antifungal agent.
- It is commonly used to treat superficial fungal infections, including onychomycosis.
- Adverse cutaneous reactions are known side effects of oral terbinafine therapy.
Observation:
- A 36-year-old woman presented with a specific dermatological condition.
- The patient had recently initiated treatment with oral terbinafine for a fungal infection.
- The onset of the condition was temporally associated with terbinafine intake.
Findings:
- The patient developed acute generalized exanthematous pustulosis (AGEP).
- AGEP is a rare but serious adverse drug reaction characterized by widespread pustules on an erythematous background.
- This case highlights a potential link between oral terbinafine and AGEP.
Implications:
- Clinicians should be aware of the potential for rare, severe cutaneous reactions like AGEP with oral terbinafine.
- Early recognition and discontinuation of the offending agent are crucial for managing AGEP.
- Further pharmacovigilance is warranted to better understand the incidence and risk factors for terbinafine-induced AGEP.
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