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Related Experiment Videos

Tissue engineering: current state of clinical application.

Dario O Fauza1

  • 1Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. dario.fauza@tch.harvard.edu

Current Opinion in Pediatrics
|June 14, 2003
PubMed
Summary
This summary is machine-generated.

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Tissue engineering shows great promise but faces challenges in clinical validation and commercialization. Despite hurdles, its scientific potential suggests future integration into mainstream surgical practice.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Tissue engineering applications have seen limited validation through controlled trials.
  • The field's youth, infrastructure demands, and personnel needs hinder multicenter studies.
  • Economic viability of tissue engineering companies remains a significant challenge.

Purpose of the Study:

  • To review the current status and challenges of clinical tissue engineering applications.
  • To assess the progress and hurdles toward commercializing engineered tissues.
  • To project the future integration of tissue engineering into surgical practice.

Main Methods:

  • Analysis of existing literature on controlled trials and regulatory approvals.
  • Examination of industry trends, company development, and economic viability.

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  • Discussion of scientific promise and societal impact.

    • Main Results:

    • Few prospective trials have validated clinical tissue engineering.
    • Significant infrastructure and personnel requirements impede large-scale trials.
    • Despite FDA approval limitations, over 70 companies are actively developing products.
    • Commercialization faces hurdles before 'off-the-shelf' tissues are available.

    Conclusions:

    • Tissue engineering is a nascent field with substantial challenges.
    • Overcoming infrastructure, validation, and economic barriers is crucial.
    • The field's scientific promise indicates eventual mainstream adoption in surgery.