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Activation of the contact system in ascites from patients with gastrointestinal cancer
L Buø1, T S Karlsrud, H T Johansen
1Institute for Surgical Research, University of Oslo, Norway.
Abstract:
Our observations indicates that the plasma contact system is activated in ascites from patients with gastrointestinal cancer: Factor XII is activated, plasma kallikrein is present in complex with the protease inhibitor alpha 2-macroglobulin, and the plasma kallikrein substrate high molecular weight kininogen, is highly degraded. Contact activation seems to take place in spite of a high level of inhibition. Activation of the contact system generates mediators, which may play a role in the accumulation of ascites.
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