Related Experiment Video
Updated: Aug 10, 2026
07:07
Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
Diabetes mellitus and the dental pulp
1Academy House, Philadelphia, PA 19102, USA.
Journal of Endodontics
|June 20, 2003
Summary
Diabetes mellitus increases risks for dental pulp infections due to impaired circulation and immune response. Treating oral infections, including dental pulp issues, is crucial for better glycemic control in diabetic patients.
Area of Science:
- Endocrinology
- Oral Medicine
- Immunology
Background:
- Diabetes mellitus impairs circulation and immune function, increasing infection susceptibility.
- Diabetic patients exhibit damaged blood vessels and reduced leukocyte efficacy.
- The dental pulp's limited collateral circulation makes it vulnerable to infection.
Purpose of the Study:
- To evaluate oral manifestations of diabetes mellitus.
- To investigate the impact of diabetes on dental pulp health.
- To highlight the link between oral infections and glycemic control.
Main Methods:
- Review of clinical and radiographic studies on diabetic patients.
- Analysis of periapical lesion prevalence in diabetics versus non-diabetics.
- Examination of asymptomatic tooth infection rates in poorly controlled diabetes.
Main Results:
- Diabetics show a higher prevalence of periapical lesions.
- A significant rate of asymptomatic tooth infections was observed in diabetics with poor glycemic control.
- Increased local inflammation exacerbates diabetes, requiring insulin adjustment.
Conclusions:
- Dental pulp infections pose a significant risk for individuals with diabetes mellitus.
- Effective management of oral infections, including dental pulp infections, is essential for improving glycemic control.
- Periapical lesions in diabetics heal effectively when diabetes mellitus is therapeutically controlled.
Related Concept Videos
01:21Tooth Anatomy
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:20Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:26Diabetes Mellitus: Introduction
Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
01:22Complications of Diabetes Mellitus
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
01:22Diabetic Neuropathy
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...