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Related Experiment Videos

Epigenomic replication: linking epigenetics to DNA replication.

Adrian J McNairn1, David M Gilbert

  • 1Department of Biochemistry and Molecular Biology, S.U.N.Y. Syracuse, NY 13210, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 20, 2003
PubMed
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The genome and epigenome are replicated during S-phase, a critical window for genetic regulation. Spatiotemporal control of chromatin modifiers at replication forks may ensure epigenetic inheritance.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cell Biology

Background:

  • Genetic and epigenetic information must be faithfully replicated during cell division.
  • Epigenetic information, carried by chromatin proteins, is crucial for gene regulation and cell differentiation.
  • Both genome and epigenome synthesis occur at the replication fork during S-phase.

Purpose of the Study:

  • To investigate the role of S-phase events in maintaining or altering genetic and epigenetic states.
  • To explore how cells distinguish between different chromatin states.
  • To understand the significance of localized chromatin-modifying proteins at replication forks.

Main Methods:

  • Review of recent studies on chromatin modifying proteins.
  • Analysis of the spatiotemporal regulation of these proteins during S-phase.

Related Experiment Videos

  • Correlation of replication timing of chromosome domains with epigenetic inheritance.

    • Main Results:

    • Certain chromatin modifying proteins localize to replication forks at specific times during S-phase.
    • Transcriptionally active and inactive chromosome domains replicate at distinct times in S-phase.
    • This precise timing suggests a mechanism for epigenetic inheritance.

    Conclusions:

    • The localization and activity of chromatin modifying proteins at replication forks are tightly regulated during S-phase.
    • This spatiotemporal regulation is likely integral to the maintenance of epigenetic inheritance.
    • Understanding these processes is key to comprehending cell differentiation and identity.