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Further characterization of endopeptidase H2 a serine proteinase from human urine
D E Casarini1, C E Fellows, R C Stella
1Disciplina de Nefrologia, Escola Paulista de Medicina, São Paulo, Brazil.
Agents and Actions. Supplements
|January 1, 1992
Abstract:
A human urine serine proteinase chymotrypsin like hydrolyzes the peptide bonds: Phe-Ser (kinin); Gly-Gly, Leu-Arg, Phe-Lys (neuropeptides) and Gln-Gln (substance P). Endopeptidase H2 hydrolyzes better oligopeptides with 4 to 18 aminoacid residues than larger peptides, it does not hydrolyzes kininogen or proenkephalin. The enzyme behaves as an oligoendopeptidase.