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A new synthetic route to phomoidride B and its derivatives
Yuki Hayashi1, Tetsuji Itoh, Tohru Fukuyama
1Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. [reaction: see text]
Organic Letters
|June 21, 2003
Abstract:
We have developed a new synthetic route to phomoidride B, which could also be applied to the synthesis of phomoidride B derivatives using Pd-catalyzed coupling reaction of a thiolester with an organozinc reagent. In addition, direct construction of the maleic anhydride moiety has been achieved by a Pd-catalyzed carbonylation reaction.