[ICA incidence in relatives of patients with diabetes type 1]

Diabetes type 1 is the authoimmunological disease, which develops in persons with genetical predisposition. Typing persons with higher risk of diabetes type 1 is usually based on immunological markers. The ICA are most often determined. The aim of the study was determination of ICA incidence and levels in the group of relatives of patients with diabetes type 1. The studied group consisted of 512 relatives of patients with diabetes type 1. The ICA incidence in 61 relatives was found (11.9%). The incidence and the levels of ICA were similar in both sexes. Majority of males with positive ICA (80%) was younger (0-20), while majority of females with positive ICA (70.97%) was older (21-40 years) (p=0.007). In brothers ICA antibodies were more frequent than in sisters.