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The sigma B regulon influences internalization of Staphylococcus aureus by osteoblasts
Sean P Nair1, Markus Bischoff, Maria M Senn
1Cellular Microbiology Research Group, Eastman Dental Institute for Oral Health Care Sciences, University College London, London WC1X 8LD, United Kingdom. snair@eastman.ucl.ac.uk
Infection and Immunity
|June 24, 2003
Abstract:
Individual strains of Staphylococcus aureus have different capacities to become internalized by osteoblasts. Here we report that the levels of sigma(B) expressed by S. aureus correlate with the capacity of this bacterium to be internalized by osteoblasts. However, sigma(B) is not essential for internalization and does not necessarily account for the differences in the capacities of strains to be internalized.