Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventricular reconstruction for ischemic cardiomyopathy.

Lynda L Mickleborough1, Naeem Merchant, Yves Provost

  • 1Division of Cardiovascular Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. lynda.mickleborough@uhn.on.ca

The Annals of Thoracic Surgery
|June 25, 2003
PubMed
Summary

Left ventricular reconstruction improves heart function in patients with coronary artery disease and poor ejection fraction. This surgical approach offers significant survival benefits and reduced symptoms for selected individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence and Significance of Pancreatic Iron in Transfusion-Dependent Sickle Cell Disease.

Pediatric blood & cancer·2025
Same author

Transfusional hemosiderosis in childhood cancer patients and survivors.

Pediatric blood & cancer·2024
Same author

Significant pituitary siderosis is common in transfusion-dependent sickle cell disease.

Blood·2024
Same author

Monkeypox associated myocarditis: A case report.

IDCases·2022
Same author

Natural History of Myocardial Injury After COVID-19 Vaccine-Associated Myocarditis.

The Canadian journal of cardiology·2022
Same author

Stress Perfusion Cardiac Magnetic Resonance Imaging With a 3.0-Tesla Scanner for Myocardial Viability in a Patient With a Conditional Pacemaker.

CJC open·2022

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Heart Failure Pathophysiology

Background:

  • Ischemic cardiomyopathy, resulting from coronary artery disease and myocardial infarction, often leads to poor left ventricular function.
  • Akinetic or dyskinetic nonfunctioning portions of the left ventricle contribute to reduced cardiac output and heart failure symptoms.
  • Ventricular arrhythmias are common and prognostically significant in patients with ischemic cardiomyopathy.

Purpose of the Study:

  • To review the pathophysiology of ischemic cardiomyopathy.
  • To establish guidelines for patient selection and preoperative assessment for left ventricular reconstruction.
  • To describe the surgical technique and evaluate the outcomes of left ventricular reconstruction, including adjunctive arrhythmia ablation.

Main Methods:

Related Experiment Videos

  • Surgical resection or exclusion of akinetic/dyskinetic ventricular segments.
  • Restoration of normal left ventricular size and shape.
  • Visually directed ablation for ventricular arrhythmias in cases of significant septal scarring.

Main Results:

  • Significant reduction in left ventricular volume.
  • Increase in ejection fraction and improvement in apical geometry.
  • Low operative mortality with 5-year survival of 84% and freedom from sudden death of 96%.

Conclusions:

  • Left ventricular reconstruction is a safe and effective procedure for selected patients with ischemic cardiomyopathy.
  • The surgery leads to significant improvements in left ventricular function, reduced symptoms, and enhanced long-term survival.
  • Ventricular reconstruction should be considered for patients with coronary artery disease and akinetic or dyskinetic scar.