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[Naltrexone implants--a pilot project].

Helge Waal1, Asbjørg S Christophersen, Grethe Frogopsahl

  • 1Instituttgruppe for psykiatri, Seksjon for kliniske rusmiddelproblemer, Universitetet i Oslo, MARIO, Kirkeveien 166, 0407 Oslo. helge.waal@psykiatri.uio.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|June 25, 2003
PubMed
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Naltrexone implants provide extended protection against heroin relapse for 35-80 days. While generally safe, repeat implants may cause tissue reactions, necessitating careful patient evaluation and follow-up.

Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Toxicology

Context:

  • Growing trend of Norwegian heroin addicts seeking naltrexone implants internationally without documentation.
  • Need for standardized safety and efficacy data on naltrexone implants.

Purpose:

  • To evaluate the duration of naltrexone protection provided by implants.
  • To assess the safety profile and patient tolerance of naltrexone implants.
  • To investigate adverse events associated with naltrexone implants.

Summary:

  • A study involving 10 patients and 21 naltrexone implants demonstrated plasma naltrexone levels for 35-80 days.
  • Side effects were minimal; however, two patients experienced abstinence reactions due to inadequate detoxification, and two had repeat implants removed due to tissue reactions.

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  • One patient contracted hepatitis C, and another showed transient transaminase elevation after polysubstance use; most patients exhibited no hepatic toxicity.

    • Impact:

    • Naltrexone implants offer a viable strategy for sustained opioid antagonist therapy.
    • Highlights the importance of thorough patient screening and integrated follow-up care for implant recipients.
    • Identifies potential complications like tissue reactions to repeat implants, informing clinical practice.