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[Multi-section magnetic susceptibility perfusion echo-planar imaging of the breast]
Mitsuhiro Tozaki1, Yasushi Fukuda, Kunihiko Fukuda
1Department of Radiology, The Jikei University School of Medicine.
Purpose:
To examine the diagnostic value of multi-section magnetic susceptibility perfusion echo-planar imaging (perfusion EPI) in patients with breast tumors prior to T1-weighted dynamic MRI.
Materials And Methods:
MR imaging was performed in 75 patients with pathologically proved breast tumors using a 1.5 Tesla MR unit (MAGNETOM Symphony, Siemens Medical Solutions, Erlangen, Germany). Perfusion EPI was carried out before, during, and after the bolus injection of 0.1 mmol Gd-DTPA/kg. Two patients had two carcinomas in the same breast, one patient had both a benign and a malignant lesion in the same breast, and two patients had lesions in both breasts. Histopathological diagnosis was non-invasive ductal carcinoma in 9, invasive carcinoma in 49, and benign lesion in 22. The first-pass signal intensity loss of the lesions was calculated by perfusion EPI.
Results:
Fifty-one of 58 carcinomas but only 4 of 22 benign lesions had a signal intensity loss of 20% or more during the first pass, for a sensitivity of 88% and specificity of 82%
Conclusion:
Perfusion EPI can be used as a useful diagnostic tool for differentiation between benign and malignant lesions. It is also thought to be a promising method for diagnosing multifocal breast lesions.