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[Lymphocyte apoptosis in atopic dermatitis treated with transfer factor]
Jesús García Angeles1, Graciela Flores Sandoval, Modesto Orea Solano
1Departamento de Alergia e Inmunologia Clinica, Hospital Regional Lic. Adolfo López Mateos, ISSSTE, Av. Universidad 1321, col. Florida, CP 01030, México, DF.
Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|June 26, 2003
Summary
This study found that lymphocyte apoptosis did not differ significantly in patients with atopic dermatitis before or after transfer factor treatment. However, transfer factor treatment did significantly reduce the severity of atopic dermatitis symptoms.
Area of Science:
- Immunology
- Dermatology
- Cell Biology
Background:
- Atopic dermatitis is an inflammatory skin condition where T lymphocytes play a key role in regulating inflammation.
- Understanding lymphocyte behavior is crucial for developing effective treatments for atopic dermatitis.
Purpose of the Study:
- To investigate the role of lymphocyte apoptosis in patients with moderate to severe atopic dermatitis.
- To evaluate changes in lymphocyte apoptosis before and after treatment with transfer factor.
- To assess the impact of transfer factor on the severity of atopic dermatitis.
Main Methods:
- The study included 15 patients with moderate to severe atopic dermatitis and 15 healthy controls.
- Lymphocyte apoptosis was measured using annexin and TUNEL assays, and CD95 expression was analyzed.
- Patients received a three-month course of transfer factor, with symptom severity assessed using the SCORAD scale.
Main Results:
- No significant differences in lymphocyte apoptosis were observed between patients and controls, either before or after treatment.
- CD95 expression on lymphocytes also showed no significant changes post-treatment.
- A significant reduction in atopic dermatitis severity (SCORAD score) was noted after transfer factor therapy.
Conclusions:
- Lymphocyte apoptosis is not significantly altered in patients with atopic dermatitis treated with transfer factor.
- Transfer factor treatment effectively reduces the clinical severity of atopic dermatitis.
- Further research may explore other mechanisms by which transfer factor exerts its therapeutic effects in atopic dermatitis.