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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
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Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

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Published on: June 29, 2021

Transfer factor and allergy.

Javier Gómez Vera1, Raúl Chávez Sánchez, Graciela Flores Sandoval

  • 1Immunology and Allergy Unit, Adolfo Lopez Mateos Hospital, ISSSTE, Mexico. iestrada@encb.ipn.mx.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|September 28, 2011
PubMed
Summary

Transfer factor (TF) may restore the Th1/Th2 balance in allergic responses. This immune modulation may improve regulatory mechanisms and clinical outcomes for patients with allergies.

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Area of Science:

  • Immunology
  • Allergy Research
  • Cellular Immunology

Background:

  • Allergy development is linked to an imbalance between T helper 1 (Th1) and T helper 2 (Th2) cells.
  • Other lymphocyte subsets, including Th17, CD4 FOXP3, and Th9 cells, may also influence allergic responses.
  • Immune regulatory processes are key targets for therapeutic interventions aimed at resolving allergic reactions.

Purpose of the Study:

  • To investigate the potential of Transfer Factor (TF) in restoring immune balance in allergic conditions.
  • To evaluate TF's role in improving immune regulatory mechanisms and clinical outcomes for allergy patients.

Main Methods:

  • Literature review of current knowledge on Transfer Factor (TF) and its effects on immune balance.
  • Analysis of preliminary data showing TF's induction of mRNA expression for IFN-γ, osteopontin, RANTES, and hBD-2 in healthy subjects.
  • Clinical observation of patients receiving TF alongside conventional treatment for allergic diseases.

Main Results:

  • TF may restore the Th1/Th2 balance and enhance immune regulatory functions.
  • Preliminary results indicate TF induces specific mRNA expressions (IFN-γ, osteopontin, RANTES, hBD-2) in humans.
  • Patients treated with TF alongside conventional therapy showed improved clinical evolution compared to those without TF.

Conclusions:

  • Transfer Factor (TF) shows promise in modulating immune responses relevant to allergies.
  • TF may provide essential regulatory elements lacking in allergic patients, promoting balanced immune responses.
  • Adding TF to standard treatments may lead to faster and more effective resolution of allergic reactions.