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Effect of glycine on the immune response of the experimentally diabetic rats
Diana Lezcano Meza1, Luis Terán Ortiz, Guillermo Carvajal Sandoval
1Respiratory Diseases National Institute of Mexico, Xenotransplantation Laboratory, Infantile Hospital of Mexico Federico Gomez, Mexico. dianalm@iner.gob.mx
Background:
Hyperglycemia induces protein glycation, disturbing its function, additionally, the glycated products (AGEs) induce by themselves proinflammatory cytokine release that are responsible for insulin resistance. Glycine has been successfully used in diabetic patients to competitively reduce hemoglobin glycation.
Objectives:
To assess hyperglycemia impact on the immune response and to evaluate if it is possible to reverse it by means of glycine administration.
Material And Methods:
Streptozotocin-induced diabetic rats, with and without glycine administration were challenged with sheep red blood cells, and specific antibody producing cells were accounted. Normal rats were challenged as controls.
Results:
Induced diabetes modifies significantly the humoral immune response capacity versus sheep red blood cells. Also, glycine administration prevents against this deleterious effect.
Conclusions:
Glycine could be an important therapeutic resource among diabetics to avoid the characteristic immunodeficiencies of this disease.
