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Related Experiment Videos

Multiple sequence alignment with the Clustal series of programs.

Ramu Chenna1, Hideaki Sugawara, Tadashi Koike

  • 1European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

Nucleic Acids Research
|June 26, 2003
PubMed
Summary
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Clustal programs offer accurate multiple sequence alignment and phylogenetic tree construction for molecular biology. Recent updates enhance user-friendliness and computational speed, with web servers improving accessibility.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Clustal programs are essential tools for multiple sequence alignment and phylogenetic tree generation in molecular biology.
  • Their widespread use is attributed to accuracy, robustness, portability, and user-friendliness.

Purpose of the Study:

  • To highlight the features and accessibility of the Clustal series of programs.
  • To inform users about recent enhancements and available web server implementations.

Main Methods:

  • The Clustal programs perform multiple sequence alignment for nucleic acid and protein sequences.
  • Phylogenetic trees are constructed using the aligned sequences.
  • New features and web server accessibility are described.

Related Experiment Videos

Main Results:

  • Clustal programs provide accurate and robust sequence alignment and phylogenetic analysis.
  • New features include NEXUS and FASTA format output, range number printing, and faster tree calculations.
  • Web server implementations, such as at the EBI, increase program accessibility.

Conclusions:

  • The Clustal series remains a vital and evolving tool for molecular biologists.
  • Enhanced features and web accessibility contribute to its continued popularity and utility.