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Synthesis and characterization of oligodeoxyribonucleotides carrying arrays of intercalating groups
1Department of Chemistry, Faculty of Science, Tokyo Metropolitan University, 1-1 Minamiohsawa, Hachioji, Tokyo 192-0397, Japan.
Nucleic Acids Research. Supplement (2001)
|July 3, 2003
Abstract:
A novel strategy for attaching the functional groups to oligodeoxyribonucleotides (ODNs) is described. A thymidine carrying anthraquinone derivative at the N3 position (AnT) was synthesized and introduced into ODNs using the phosphoramidite method on a DNA synthesizer. Py-Pu-Py type triplex formation of ODNs was enhanced by attaching AnT to the 5'-end of the third strand.