Related Experiment Videos
Control of tRNA function by antisense PNA derivatives
K Ninomiya1, T Endo, T Hohsaka
1Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan.
Nucleic Acids Research. Supplement (2001)
|July 3, 2003
Abstract:
The interaction of antisense peptide nucleic acid (PNA) with yeast tRNA(Phe) was investigated. A 6-mer PNA complementary to the 3'-terminal sequence including the 73ACCA end hybridized to the tRNA. While the PNA with a single mismatch did not. PNA is a promising candidate for controlling tRNA functions by the sequence-specific hybridization.