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Published on: February 28, 2019
[The expression of proliferating cell nuclear antigen and Bcl-2 oncoprotein in nasopharyngeal carcinoma]
Qing Cheng1, Xiang Huang, Jibao Wang
1Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Objective:
To observe PCNA, Bcl-2 gene expression and their relationship with clinicopathologic factors in primary nasopharyngeal carcinoma(NPC).
Method:
PCNA, Bcl-2 proteins were assayed with immunohistochemical technique.
Result:
The expression of Bcl-2 protein was 9.5% in chronic inflammation of nasopharyngeal epithelium(CINE), which was significantly lower than it in NPCs with 83.1% (P < 0.01). In NPCs, we could find PCNA and Bcl-2 expression were significantly negatively correlated with each other(rs = -0.41, P < 0.01). In our study, there was some correlation in the grade of PCNA proliferating index(PI) with the clinical stages or cervical lymph node metastasis of NPCs.
Conclusion:
PCNA PI may represent the proliferative state of NPC, Bcl-2 protein may be a better tumor marker of NPC, all of them may play important roles in the pathogenesis of nasopharyngeal carcinoma.
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