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Zinc-naproxen complex: synthesis, physicochemical and biological evaluation.
Jyoti Sharma1, Anil K Singla, S Dhawan
1University Institute of Pharmaceutical Sciences, Punjab University, Chandigarh-160014, India.
International Journal of Pharmaceutics
|July 5, 2003
Summary
Naproxen can cause ulcers, but a new zinc complex shows reduced ulcer formation and enhanced anti-inflammatory effects. This zinc naproxen complex may be a safer alternative to naproxen alone.
Area of Science:
- Pharmacology
- Materials Science
Background:
- Naproxen, a common nonsteroidal anti-inflammatory drug (NSAID), is associated with gastrointestinal ulceration.
- Zinc ions possess known anti-ulcer and anti-inflammatory properties.
Purpose of the Study:
- To synthesize and characterize a zinc complex of naproxen.
- To evaluate the anti-ulcer and anti-inflammatory efficacy of the zinc naproxen complex compared to naproxen alone.
Main Methods:
- Synthesis of zinc naproxen complex.
- Structural characterization using IR, NMR (1H, 13C), UV, DSC, atomic absorption spectroscopy, and elemental analysis.
- Assessment of anti-inflammatory activity via carrageenan-induced hind paw edema model and anti-ulcer activity by lesion index (LI).
Main Results:
- The zinc naproxen complex was successfully synthesized and characterized.
- The complex demonstrated significantly improved anti-inflammatory activity compared to naproxen and a physical mixture.
- The zinc complex significantly reduced ulcer formation (lesion index) compared to naproxen and the physical mixture.
Conclusions:
- The synthesized zinc naproxen complex exhibits enhanced anti-inflammatory and significant anti-ulcer properties.
- The zinc complex represents a potentially safer and more effective therapeutic option than naproxen alone.
- Further research into this complex could lead to improved NSAID formulations with reduced gastrointestinal side effects.