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Soluble HLA-G1 at the materno-foetal interface--a review
P Le Bouteiller1, F Legrand-Abravanel, C Solier
1INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, France. Philippe.Le-Bouteiller@toulouse.inserm.fr
Placenta
|July 5, 2003
Abstract:
HLA-G differs from the other MHC class I genes. This includes a unique promoter region, a restricted constitutive tissular distribution, the translation of different membrane-bound and soluble isoforms, a shortened cytoplasmic tail and a minimal polymorphim. Soluble HLA-G1 is an immunosuppressive molecule inducing apoptosis of activated CD8(+) T cells and down-modulating CD4(+) T cell proliferation. Soluble HLA-G1 may also contribute to the control of implantation.