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Mast cell tumors in the dog
Cheryl A London1, Bernard Seguin
1Department of Surgical and Radiological Sciences, 2112 Tupper Hall, One Shields Avenue, University of California at Davis, Davis, CA 95616, USA. calondon@ucdavis.edu
Summary
Mast cell tumors (MCTs) are common in dogs, varying from benign to aggressive. Current treatments are ineffective for high-grade MCTs, highlighting the need for better understanding and therapeutic strategies.
Area of Science:
- Veterinary Oncology
- Canine Pathology
Background:
- Mast cell tumors (MCTs) represent up to 20% of canine skin tumors.
- MCTs exhibit a wide spectrum of behavior, from benign to highly aggressive.
- Aggressive MCTs can metastasize and lead to fatal systemic disease.
Purpose of the Study:
- To review the current understanding of mast cell tumor (MCT) biology in dogs.
- To discuss diagnosis, staging, and prognostic indicators for canine MCTs.
- To outline appropriate treatment planning for canine MCTs.
Main Methods:
- Literature review of current research on canine mast cell tumors.
- Analysis of diagnostic and staging protocols.
- Evaluation of prognostic factors and treatment strategies.
Main Results:
- Mast cell tumors (MCTs) are the most frequent skin tumors in dogs.
- Low-grade MCTs are often curable with surgery and/or radiation.
- Effective treatments for high-grade canine MCTs remain limited.
Conclusions:
- A comprehensive understanding of MCT biology is crucial for effective management.
- Accurate diagnosis, staging, and prognostic assessment are vital for treatment planning.
- Further research is needed to develop effective therapies for aggressive canine MCTs.