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Immunotoxins to human small-cell lung cancer
E J Wawrzynczak1, E J Derbyshire
1Drug Targeting Laboratory, Institute of Cancer Research, Sutton, Surrey, UK.
Cell Biophysics
|August 1, 1992
Abstract:
Ricin A chain ITs directed against a variety of the common cell-surface antigens associated with SCLC exerted selective toxic effects on SCLC cell lines. The potency of the cytotoxic effects matched or exceeded that previously reported for ricin A chain ITs directed against identical or similar antigens on other types of carcinoma, suggesting that SCLC may be uniquely sensitive to this type of IT.