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Related Experiment Videos

Left-right asymmetry: nodal points.

Mark Mercola1

  • 1Stem Cell and Regeneration Program, The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA. mmercola@burnham.org

Journal of Cell Science
|July 15, 2003
PubMed
Summary
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Researchers are exploring early steps in embryonic left-right asymmetry. They speculate monocilia, gap junctions, and polycystin-2 form a signaling pathway for propagating these crucial developmental cues.

Area of Science:

  • Developmental biology
  • Cellular signaling
  • Embryogenesis

Background:

  • Left-right asymmetry in visceral organs is established by gene expression during embryogenesis.
  • The earliest steps determining this asymmetry are under investigation.
  • The coordination of proteins and structures controlling laterality is not well understood.

Purpose of the Study:

  • To characterize the earliest steps in asymmetry determination.
  • To investigate how cellular components coordinate to control organ laterality.
  • To propose a signaling pathway for propagating left-right cues.

Main Methods:

  • Literature review and comparative analysis of intercellular signaling.
  • Speculative model development based on known cellular mechanisms.

Related Experiment Videos

  • Focus on monocilia, gap junction communication, and polycystin-2.

    • Main Results:

    • Identification of key players in asymmetry determination: monocilia, gap junction communication, and polycystin-2.
    • Hypothesized role of these components in a conserved signaling pathway.
    • Extracellular fluid flow and membrane voltage potential are implicated physiological processes.

    Conclusions:

    • Monocilia, gap junction communication, and polycystin-2 likely participate in a signaling pathway.
    • This pathway may propagate left-right cues through multicellular fields.
    • Further research is needed to confirm the proposed signaling mechanism in asymmetry determination.