Related Experiment Videos
Isoprenoid pathway related cascade in multiple myeloma
Ravi kumar Kurup1, Rekha A Nair, Parameswara Achutha Kurup
1Department of Neurology, Medical College Hospital, Kerala, India.
Pathology Oncology Research : POR
|July 15, 2003
Summary
Multiple myeloma involves altered isoprenoid metabolism, with elevated digoxin and dolichol but reduced ubiquinone. These changes, along with metabolic shifts, may contribute to the disease
Area of Science:
- Biochemistry
- Oncology
- Metabolomics
Background:
- Multiple myeloma is a hematological malignancy characterized by uncontrolled plasma cell proliferation.
- The role of isoprenoid pathway metabolites and their impact on cellular processes in multiple myeloma pathogenesis is not fully understood.
Purpose of the Study:
- To investigate alterations in the isoprenoid pathway and its metabolites (digoxin, dolichol, ubiquinone) in multiple myeloma.
- To assess associated changes in tyrosine and tryptophan catabolites, glycoconjugate metabolism, red blood cell (RBC) membrane composition, and free radical metabolism.
Main Methods:
- Analysis of isoprenoid pathway metabolites.
- Assessment of tyrosine and tryptophan catabolites.
- Evaluation of glycoconjugate metabolism, RBC membrane composition, and free radical metabolism markers.
Main Results:
- Elevated plasma HMG CoA reductase activity, serum digoxin, and dolichol.
- Reduced RBC membrane Na+ - K+ ATPase activity and serum ubiquinone levels.
- Significant alterations in tryptophan/tyrosine catabolites, glycoconjugate metabolism, RBC membrane composition, and free radical metabolism markers.
Conclusions:
- Hyperdigoxinemia, altered glycoconjugate metabolism (dolichol-related), and ubiquinone deficiency-induced mitochondrial dysfunction may contribute to multiple myeloma pathogenesis.
- The observed biochemical changes could be either a cause or a consequence of multiple myeloma.