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Updated: Sep 23, 2026
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Published on: October 23, 2019
Topical mitomycin C-induced inhibition of postlaminectomy peridural fibrosis in rabbits
Fikret Dogulu1, Gokhan Kurt, Hakan Emmez
1Department of Neurosurgery, Gazi University School of Medicine, Ankara, Turkey. fdogulu@hotmail.com
Object:
The authors conducted a study to determine the effectiveness of mitomycin C in preventing postlaminectomy peridural fibrosis in rabbits.
Methods:
Laminectomies were performed at L-4 in 12 rabbits. Color-coded cotton pads soaked either with 0.02% mitomycin C or saline were applied in a blinded fashion to the operative sites, with saline-treated laminectomy sites serving as controls. The rabbits were killed 30 days after surgery. The extent of peridural fibrosis was evaluated by histological analysis. The mitomycin C-treated sites showed significantly decreased peridural fibrosis.
Conclusions:
Peridural fibrosis can be a devastating condition that develops after laminectomy. Topical application of mitomycin C may be a successful method of preventing postlaminectomy peridural fibrosis.
