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Clinical, radiographic, histologic, and histomorphometric comparison of PepGen P-15 particulate and PepGen P-15 flow
Jack Hahn1, Michael D Rohrer, Andrew J Tofe
1Division of Oral & Maxillofacial Pathology, University of Minnesota School of Dentistry, Minneapolis, Minnesota, USA. cid@iglou.com
Purpose:
Although the efficacy of PepGen P-15 particulate has been conclusively demonstrated in two multicenter clinical studies, the effect of a new hydrogel formulation containing PepGen P-15 on bone repair has not been previously demonstrated.
Materials And Methods:
PepGen P-15 Flow contains PepGen P-15 particulate in a biocompatible hydrogel, which provides spacing between the particles. In this case study, bone repair of both PepGen P-15 particles and PepGen P-15 Flow was compared to natural bone in same-mouth extraction sockets.
Results:
The radiographic, histologic, and histomorphometric evaluations showed enhanced bone formation and faster particle resorption with PepGen P-15 Flow compared to the PepGen P-15 particulate.
Conclusion:
The accelerated bone formation by PepGen P-15 Flow may provide faster implant placement.