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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

[Research advances on inhibitor of apoptosis, survivin]

Jing Yang1, Feng-Xuan Liu, Xiao-Chu Yan

  • 1Pathology Institute, Southwest Hospital, The Third Military Medical University, Chongqing, 400038, PR China. yangjing16@yahoo.com

AI Zheng = Aizheng = Chinese Journal of Cancer
|July 18, 2003
PubMed

Insights

Survivin, a key inhibitor of apoptosis, regulates cell division and promotes cancer growth. Targeting survivin shows promise for cancer treatment by inducing cell death and enhancing therapy effectiveness.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Cell Biology

Background:

  • Survivin is a novel inhibitor of apoptosis.
  • Survivin expression is linked to cell cycle regulation, specifically the G(2)/M phase.
  • Increased survivin expression correlates with poor prognosis in human cancers.

Purpose of the Study:

  • To investigate the role of survivin in cancer.
  • To explore survivin as a potential therapeutic target for cancer treatment.

Main Methods:

  • Studied survivin's association with mitotic spindle microtubules.
  • Investigated survivin's inhibition of caspase-3 and caspase-7 activity.
  • Utilized survivin-targeting antisense nucleotides and survivin mutants in vitro and in vivo.

Main Results:

  • Survivin expression is inversely correlated with apoptosis and positively correlated with proliferation and angiogenesis during tumorigenesis.
  • Survivin up-regulation predicts short survival and poor prognosis.
  • Targeting survivin induced apoptosis, reduced tumor growth, and sensitized cancer cells to chemotherapy and irradiation.

Conclusions:

  • Survivin plays a critical role in cancer development and progression.
  • Survivin represents a potential novel target for cancer diagnosis and therapy.

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