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Related Experiment Videos

Emx2 patterns the neocortex by regulating FGF positional signaling.

Tomomi Fukuchi-Shimogori1, Elizabeth A Grove

  • 1Department of Neurobiology, Pharmacology and Physiology, University of Chicago, 947 East 58th Street, MC0926, Chicago, Illinois 60637, USA.

Nature Neuroscience
|July 23, 2003
PubMed
Summary
This summary is machine-generated.

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Emx2 regulates fibroblast growth factor 8 (FGF8) to indirectly pattern the neocortical area map. Manipulating Emx2 or FGF8 levels altered the map, clarifying their roles in brain development.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Genetics

Background:

  • Fibroblast growth factor 8 (FGF8) and Emx2 are implicated in neocortical area map development.
  • Their precise roles and interactions in specifying anterior-to-posterior positional information remain unclear.

Purpose of the Study:

  • To elucidate the regulatory relationship between Emx2 and FGF8 in neocortical area map formation.
  • To determine if Emx2 acts independently or coordinately with FGF8.

Main Methods:

  • Electroporation-mediated gene transfer in living mouse embryos.
  • Overexpression of Emx2 and manipulation of FGF8 levels.
  • Utilizing a truncated FGF receptor to sequester FGF8.

Main Results:

Related Experiment Videos

  • Emx2 overexpression altered the area map only when overlapping the FGF8 source.
  • Emx2 regulates FGF8 levels: excess Emx2 decreased FGF8, while Emx2 deficiency increased FGF8.
  • Cortical domain shifts in Emx2 mutants were rescued by FGF8 sequestration.

Conclusions:

  • Emx2 plays an indirect but crucial role in neocortical area map development by regulating FGF8.
  • These findings clarify a key signaling network involved in patterning the mammalian brain's functional map.