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Pyrimidinone antibiotics--heterocyclic analogues with improved antibacterial spectrum
Michael Brands1, Yolanda Cancho Grande, Rainer Endermann
1BAYER AG, Business Group Pharma, Research, D-42096, Wuppertal, Germany. michael.brands.b@nayer.com
Bioorganic & Medicinal Chemistry Letters
|July 23, 2003
Abstract:
We report the synthesis and pharmacological evaluation of new derivatives of the natural dipeptide antibiotic TAN 1057 A,B containing heterocycles either in the beta-amino acid side chain or as mimics of the urea function. In the course of this program, we identified novel analogues that display activity towards a broader panel of Gram-positive bacteriae.