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Target selection and determination of function in structural genomics.

James D Watson1, Annabel E Todd, James Bray

  • 1EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

IUBMB Life
|July 26, 2003
PubMed
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Selecting the right protein targets is key for structural genomics. This study details methods for choosing proteins and predicting their functions using sequence and 3D structure analysis.

Area of Science:

  • Structural genomics
  • Protein structure determination
  • Biochemical function prediction

Background:

  • Protein structure determination is crucial for understanding biological processes.
  • Effective selection of target proteins is essential for the success of structural genomics projects.
  • Determining protein function enhances the value of solved structures.

Purpose of the Study:

  • To describe methods for selecting high-quality protein targets for structure determination.
  • To present computational approaches for predicting protein biochemical functions from 3D structures.

Main Methods:

  • Sensitive sequence comparison techniques for target protein selection.
  • Computational methods for biochemical function prediction from 3D protein structures.

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Main Results:

  • Identification of sensitive sequence comparison techniques for prioritizing protein targets.
  • Application of computational methods to determine likely biochemical functions of solved protein structures.

Conclusions:

  • Optimized target selection and function prediction significantly increase the value of structural genomics initiatives.
  • Integrated approaches combining sequence and structural analysis are vital for advancing protein science.