Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adipose tissue-derived therapeutics.

Jeffrey M Gimble1

  • 1Artecel Sciences, Inc., Brightleaf Square, 905 West Main Street, Box 44, Suite 25-B, Durham, NC 27701, USA. Jeffrey.M.Gimble.77@alum.dartmouth.org

Expert Opinion on Biological Therapy
|July 26, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adipose Tissue in Breast Cancer Microphysiological Models to Capture Human Diversity in Preclinical Models.

International journal of molecular sciences·2024
Same author

Isolation of Human Adipose-Derived Stromal/Stem Cells from Lipoaspirates.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Isolation of Murine Adipose-Derived Stromal/Stem Cells for Adipogenic and Osteogenic Differentiation or Flow Cytometry-Based Analysis.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Isolation of Murine Adipose-Derived Stromal/Stem Cells Using an Explant Culture Method.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Manufacturing of a Human Adipose-Derived Hydrogel.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Quality Control Assessment of Human Adipose-Derived Hydrogels.

Methods in molecular biology (Clifton, N.J.)·2024
Same journal

TNF inhibitors for the long-term management of juvenile idiopathic arthritis associated uveitis: real-life data from the ITHACA cohort.

Expert opinion on biological therapy·2026
Same journal

Type 2 inflammation and biologics: a twenty-year journey.

Expert opinion on biological therapy·2026
Same journal

Current outlook on the use of biological agents to improve outcomes in adult secondary hemophagocytic lymphohistiocytosis.

Expert opinion on biological therapy·2026
Same journal

Addressing challenges in disease management of childhood-onset systemic lupus erythematosus: the role of biologics, with primary focus on rituximab and belimumab.

Expert opinion on biological therapy·2026
Same journal

Biological drugs for the treatment of children with atopic dermatitis.

Expert opinion on biological therapy·2026
Same journal

Optimizing biologic therapy in psoriasis: dose adjustment, treatment duration, and tapering-an expert perspective.

Expert opinion on biological therapy·2026
See all related articles

Human adipose-derived adult stem (ADAS) cells are a promising source for regenerative medicine. These cells can differentiate into various cell types and serve as gene delivery vehicles, with future research focusing on large-scale production and transplantation feasibility.

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Tissue Engineering

Background:

  • Human adipose tissue is an abundant source of adult stem cells.
  • Adipose-derived adult stem (ADAS) cells are crucial for tissue engineering and regenerative medicine.
  • These cells possess multipotent differentiation capabilities.

Purpose of the Study:

  • To explore the potential of ADAS cells in regenerative medicine.
  • To investigate the characteristics and differentiation capacity of ADAS cells.
  • To identify future research directions for clinical applications of ADAS cells.

Main Methods:

  • Isolation of ADAS cells via collagenase digestion and differential centrifugation.
  • Characterization of ADAS cells based on immunophenotype (e.g., integrin beta(1), CD9).

Related Experiment Videos

  • Assessment of ADAS cell differentiation into adipocytes, chondrocytes, myocytes, neurons, and osteoblasts.

    • Main Results:

    • ADAS cells are relatively homogeneous with specific marker expression.
    • ADAS cells demonstrate multipotency, differentiating into various cell lineages.
    • ADAS cells can be transduced, showing potential as gene delivery vehicles.

    Conclusions:

    • ADAS cells hold significant promise for tissue engineering and regenerative medicine.
    • Future research should focus on developing closed system bioreactors for large-scale ADAS cell manufacturing.
    • Investigating methods to improve implant vascularization and the feasibility of allogeneic transplantation is essential for clinical development.