Related Experiment Video

Updated: Aug 10, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

[Experience with vaccine prophylaxis of hepatitis B among different groups of children]

I A Moskovskaia1, L E Kuzina, T V Anichkina

  • 1Hepatological Center of Infectious Hospital No. 2, Tula, Russia.

Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|July 31, 2003
PubMed

Insights

This study evaluated hepatitis B vaccines in newborns, finding high immunological activity and safety. All tested vaccines demonstrated effectiveness in generating protective antibody levels against hepatitis B virus.

Area of Science:

  • Immunology
  • Vaccinology
  • Hepatology

Background:

  • Hepatitis B remains a significant global health concern.
  • Neonatal immunization is crucial for preventing vertical transmission and lifelong infection.
  • Evaluating the immunogenicity of different hepatitis B vaccines in infants is essential.

Purpose of the Study:

  • To assess and compare the immunological activity of three distinct hepatitis B vaccines in newborn infants.
  • To determine the safety and efficacy of different immunization schedules for hepatitis B vaccination.
  • To evaluate vaccine effectiveness in infants born to mothers with persistent HBs-antigenemia.

Main Methods:

  • Immunological evaluation of Engerix B, Combiotech, and Euvax B vaccines in newborn infants.
  • Administration of vaccines according to two different schedules: 0-1-2-12 months and 0-1-6 months.
  • Detection and quantification of anti-HBs antibodies post-immunization using serological assays.

Main Results:

  • Overall, 93.8% of infants developed protective anti-HBs antibody levels after completing the immunization course.
  • Engerix B showed high immunogenicity in infants of HBs-antigen-positive mothers (84.6% with >1000 IU/L anti-HBs) using the 0-1-2-12 month schedule.
  • A combined Combiotech and Euvax B schedule (0-1-6 months) resulted in protective anti-HBs levels in all infants.

Conclusions:

  • All evaluated hepatitis B vaccines demonstrated high immunological activity and safety in newborn infants.
  • Different vaccination schedules can achieve protective antibody levels, with specific schedules showing high efficacy even in high-risk infants.
  • The study confirms the effectiveness of available hepatitis B vaccines for neonatal immunization programs.

More Related Videos

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA04:11

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...